{"id":329,"date":"2017-08-24T09:57:36","date_gmt":"2017-08-24T07:57:36","guid":{"rendered":"http:\/\/wp.doc-labor.de\/?page_id=329"},"modified":"2018-01-24T16:46:08","modified_gmt":"2018-01-24T14:46:08","slug":"drinking-water-2-2-3-2","status":"publish","type":"page","link":"http:\/\/doc-labor.de\/?page_id=329","title":{"rendered":"Chemical and Pharma industry"},"content":{"rendered":"<h1>Chemical industry<\/h1>\n<p>&nbsp;<\/p>\n<p><strong>We observe a foam which cause problems. What could it be?<\/strong><\/p>\n<p>It could be protein matter from microbial activity. A single analysis of the liquified foam will clarify this. A few milliliters of sample is sufficient<\/p>\n<hr \/>\n<p><strong>We produce a chemical and have an impurity which could be an educt but we cannot measure it in this matrix. <\/strong><\/p>\n<p>If product and educt differ in retention times sufficiently then we should be able to identfy and quantfy the educt.<\/p>\n<hr \/>\n<p><strong>We have higher conductivity in a return condensate. What could it be?<\/strong><\/p>\n<p>If we get a list of all chemicals under suspicion we should be able to identify the chemcal.<\/p>\n<hr \/>\n<h3>Examples<\/h3>\n\n<div class=\"panel-group kt-accordion\" id=\"accordionname398\"><div class=\"panel panel-default panel-even\"><div class=\"panel-heading\"><a class=\"accordion-toggle collapsed\" data-toggle=\"collapse\" data-parent=\"#accordionname398\" href=\"#collapse3980\"><h5><i class=\"icon-minus kt-icon-minus primary-color\"><\/i><i class=\"icon-plus kt-icon-plus\"><\/i>Screening of technical waters<\/h5><\/a><\/div><div id=\"collapse3980\" class=\"panel-collapse collapse \"><div class=\"panel-body postclass\">\n<div class=\"row\"> <div class=\"col-md-5\">\n<p>&nbsp;<\/p>\n<p>Screening of technical waters for water-soluble organics down to the ppb concentration range.<\/p>\n<p>Virtually any organic compound which does not adsorb too strongly with the hydrophilic chromatographic phase can be quantified on the basis of organic carbon and characterised by retention time and additional UV- and nitrogen detectors.<\/p>\n<\/div><div class=\"col-md-6\">\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-330 size-full\" src=\"https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0090.png?resize=577%2C546\" alt=\"\" width=\"577\" height=\"546\" srcset=\"https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0090.png?w=577 577w, https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0090.png?resize=300%2C284 300w\" sizes=\"auto, (max-width: 577px) 100vw, 577px\" \/><\/p>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<div class=\"panel panel-default panel-odd\"><div class=\"panel-heading\"><a class=\"accordion-toggle collapsed\" data-toggle=\"collapse\" data-parent=\"#accordionname398\" href=\"#collapse3981\"><h5><i class=\"icon-minus kt-icon-minus primary-color\"><\/i><i class=\"icon-plus kt-icon-plus\"><\/i>Contaminents in process waters<\/h5><\/a><\/div><div id=\"collapse3981\" class=\"panel-collapse collapse \"><div class=\"panel-body postclass\">\n<div class=\"row\"> <div class=\"col-md-5\">\n<p>&nbsp;<\/p>\n<p>Process condensates may contain organic impurities from various production sites.<\/p>\n<p>With LC-OCD the heterogeneity and concentration of such impurities can be determined and &#8211; after comparison with suspect contaminants &#8211; assigned to specific components.<\/p>\n<\/div><div class=\"col-md-6\">\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-331 size-full\" src=\"https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0093.png?resize=577%2C772\" alt=\"\" width=\"577\" height=\"772\" srcset=\"https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0093.png?w=577 577w, https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0093.png?resize=224%2C300 224w\" sizes=\"auto, (max-width: 577px) 100vw, 577px\" \/><\/p>\n<p>&nbsp;<\/p>\n<\/div><\/div>\n<\/div><\/div><\/div><\/div>\n\n<hr \/>\n<div class=\"space_40 clearfix\"><\/div>\n<h1>Pharma industry<\/h1>\n<p>&nbsp;<\/p>\n<p><strong>TOC in our aqua purificata is well within specification. Can I be sure that all residual DOC is natural or does it contain compounds from water treatment?<\/strong><\/p>\n<p>There is a specific compound eluting a 79 min. with 35 ppb C which is most likely anthropogenic. It is suggested to analyse all steps of treatment with<br \/>\nLC-OCD.<\/p>\n<hr \/>\n<p><strong>Can we check that our active ingredient is absent in peripheral production environment? DOC in swab extracts is very high due to omnipresent fructose.<\/strong><\/p>\n<p>Compound under suspicion does not relate to all responses we find in chromatogram. Thus compound is absent (&lt; 5 ppb).<\/p>\n<hr \/>\n<h3>Examples<\/h3>\n\n<div class=\"panel-group kt-accordion\" id=\"accordionname838\"><div class=\"panel panel-default panel-even\"><div class=\"panel-heading\"><a class=\"accordion-toggle collapsed\" data-toggle=\"collapse\" data-parent=\"#accordionname838\" href=\"#collapse8380\"><h5><i class=\"icon-minus kt-icon-minus primary-color\"><\/i><i class=\"icon-plus kt-icon-plus\"><\/i>Water for Injections (WFI)<\/h5><\/a><\/div><div id=\"collapse8380\" class=\"panel-collapse collapse \"><div class=\"panel-body postclass\">\n<div class=\"row\"> <div class=\"col-md-5\">\n<p>&nbsp;<\/p>\n<p>While the target value of DOC (500 ppb) is easily met by producers, the qualitative composition may be of interest.<\/p>\n<p>Here, WFI A contains urea and ammonium.<br \/>\nFor WFI B the situation is similar but concentrations are lower.<\/p>\n<\/div><div class=\"col-md-6\">\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-332 size-full\" src=\"https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0065.png?resize=577%2C731\" alt=\"\" width=\"577\" height=\"731\" srcset=\"https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0065.png?w=577 577w, https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0065.png?resize=237%2C300 237w\" sizes=\"auto, (max-width: 577px) 100vw, 577px\" \/><\/p>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<div class=\"panel panel-default panel-odd\"><div class=\"panel-heading\"><a class=\"accordion-toggle collapsed\" data-toggle=\"collapse\" data-parent=\"#accordionname838\" href=\"#collapse8381\"><h5><i class=\"icon-minus kt-icon-minus primary-color\"><\/i><i class=\"icon-plus kt-icon-plus\"><\/i>Cleaning validation<\/h5><\/a><\/div><div id=\"collapse8381\" class=\"panel-collapse collapse \"><div class=\"panel-body postclass\">\n<div class=\"row\"> <div class=\"col-md-5\">\n<p>&nbsp;<\/p>\n<p>Swab tests are often used to control the absence of active ingredients in the production environment.<\/p>\n<p>In this case the swab extract of a canteen floor showed no indications for some specific active ingredients to be present (&lt; 5 ppb).<\/p>\n<\/div><div class=\"col-md-6\">\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-334 size-full\" src=\"https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0109.png?resize=567%2C481\" alt=\"\" width=\"567\" height=\"481\" srcset=\"https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0109.png?w=567 567w, https:\/\/i0.wp.com\/doc-labor.de\/wp-content\/uploads\/2017\/08\/img0109.png?resize=300%2C254 300w\" sizes=\"auto, (max-width: 567px) 100vw, 567px\" \/><\/p>\n<p>&nbsp;<\/p>\n<\/div><\/div>\n<\/div><\/div><\/div><\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Chemical industry &nbsp; We observe a foam which cause problems. What could it be? It could be protein matter from microbial activity. A single analysis of the liquified foam will clarify this. A few milliliters of sample is sufficient We &hellip; <a href=\"http:\/\/doc-labor.de\/?page_id=329\">Continued<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":41,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"page-fullwidth.php","meta":{"footnotes":""},"class_list":["post-329","page","type-page","status-publish","hentry"],"jetpack_shortlink":"https:\/\/wp.me\/P9uTgp-5j","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/doc-labor.de\/index.php?rest_route=\/wp\/v2\/pages\/329","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/doc-labor.de\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/doc-labor.de\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/doc-labor.de\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/doc-labor.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=329"}],"version-history":[{"count":7,"href":"http:\/\/doc-labor.de\/index.php?rest_route=\/wp\/v2\/pages\/329\/revisions"}],"predecessor-version":[{"id":625,"href":"http:\/\/doc-labor.de\/index.php?rest_route=\/wp\/v2\/pages\/329\/revisions\/625"}],"up":[{"embeddable":true,"href":"http:\/\/doc-labor.de\/index.php?rest_route=\/wp\/v2\/pages\/41"}],"wp:attachment":[{"href":"http:\/\/doc-labor.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}